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Regulation of the 2-Oxoglutarate Dehydrogenase Complex Given that the availability of 2-oxoglutarate (2-OG) plays a crucial function in the regulation of gene expression and cellular homeostasis, via its role as a cofactor for 2-oxoglutarate and Fe 2+ -dependent dioxygenases (2-OGDD), it is not surprising that the regulation of the activity of the 2-oxoglutarate dehydrogenase (OGDH) complex is under complex control