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Figure 1 also demonstrates remote pathways regulated in synchrony with methylation, in which the amount of riboflavin-activated vitamin B6 cofactor availability varies with riboflavin availability

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Counteraction of the huge liver lesions (particular lesions presentation depending on the paracetamol [61], diclofenac, ibuprofen (i.e., hepatomegaly) [107], celecoxib [105], and insulin (i.e., calcification) [62]) and gastrointestinal lesions (i.e., diclofenac [108], ibuprofen [107], celecoxib [105], insulin [62]) can be a proof of the concept

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