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A lack of riboflavin can show up as: angular cheilitis (cracks at the corners of the mouth) anemia burning mouth sore throat cataracts Riboflavin deficiency can also cause problems with iron absorption, leading to iron-deficiency anemia

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Since exogenous supplementation of GSH is not effective, modulation of glutathione biosynthesis by withanolide A could be of much therapeutic interest and can be used as a prophylactic to prevent/cure neurodegenerative disorders invoked by elevated oxidative insults in hypobaric hypoxia and other similar pathological condition