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This may be important since without therapy, the occluded superior sagittal sinus rapidly provoked a particular syndrome, the severe brain disturbances, brain swelling and lesions (i.e., confluent infarction encompassing most of the cerebral cortex) and highly increased positive pressure values and thrombosis in the superior sagittal sinus

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Therefore, despite its promising experimental profile, clinical translation will require well-designed human studies, including pharmacokinetic, dose–response, safety, and drug interaction evaluations

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