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[Google Scholar] 82.Ruenzi M., Stolte M., Veljaca M., Oreskovic K., Peterson J., Ulcerative Colitis Study Group A multicenter, randomized, double blind, placebo controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis

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NA cannot be salvaged into NAD + any longer if it is N-methylated by NNMT, so the methylation of NA impairs the abundance of free NAD + and then affects the activities of these NAD + -consuming enzymes [19]