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Research demonstrates tesofensine increases 24-hour fat oxidation by approximately 15% while reducing protein oxidation, indicating a favorable shift in substrate utilization toward lipid metabolism

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Palmitoylated GSDMD-FL/NT is recruited to the mitochondria to form a pore, which increases ROS production, and high ROS in turn increases ZDHHC5 and ZDHHC9, leading to more GSDMD palmitoylation