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Future studies will further validate the direct target of SAC and its specific regulatory mechanism on the Keap1/Nrf2 signaling pathway by constructing KEAP1 mutants and performing nuclear/cytoplasmic fractionation

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The dynamin-related protein (Drp-1) and its mitochondrial adaptor fission protein 1 (Fis-1) are the main responsible for mitochondrial fission, a process positively related to mitochondrial fragmentation and apoptosis (Frank et al., 2001