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A 2025 systematic review by Sarkar, Yadav, and colleagues in the International Journal of Dermatology characterized topical (0.5%) and oral (250–500 mg/day) glutathione as moderately effective for skin lightening while explicitly stating that intravenous glutathione is contraindicated due to lack of efficacy and adverse side effects, citing a single placebo-controlled IV study with marginal results (37.5% vs
