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By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance (80)
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“Our study provides the first direct evidence of role of SIBO and endotoxemia (LPS) and its relation with TLR signaling genes and liver histology in patients with non-alcoholic fatty liver.” Parasitic infections, IBS, colitis, food allergies also contribute to higher histamine levels: “Mastocytosis and presumably elevated availability of histamine are present in microscopic colitis, parasitic infections, IBS, and no doubt additional functional gastrointestinal disorders associated with symptoms of cramping abdominal pain, watery diarrhea, and defecation urgency.” (source) Is histamine bad and something we have to fight
