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Significance of the pleiotropic beneficial effects for Robert’s concept (stomach cytoprotection/adaptative cytoprotection → organoprotection) and Selye’s stress coping response concept Of note, Robert’s concept (stomach cytoprotection/adaptative cytoprotection → organoprotection) on which more focus is put on may be more workable

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True as this may be, chronic FOXO4 reduction is not advisable as FOXOs play a role in DNA-damage repair and Foxo4−/− mice are susceptible to acute damage(Zhou et al., 2009)