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The schematic illustrates the sequential phases of wound healing and the interplay between key cellular actors (neutrophils, macrophages, fibroblasts, keratinocytes, endothelial cells) and cytokines (e.g., TNF-α, IL-6, TGF-β, IL-10)

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Thus, in the early 1990s, pentadecapeptide BPC 157 [1,3,4,9,32,33,34,92] appeared as a late offshoot of the cytoprotection–organoprotection concept of Robert and Szabo [32,33,34,35,36,37,38,39,40,41,42], for epithelial and endothelial protection