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Selectivity vs full GH: absence of anabolic and metabolic effects The critical and scientifically remarkable point of AOD-9604 is the absence of undesirable collateral effects of full GH : - No plasma IGF-1 elevation — no effect on hepatic GHR/JAK2/STAT5 axis generating IGF-1

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All signals were visualized signal by adding the chemiluminescent ECL substrate (Boster Biological Technology, CA, USA) and exposure to X-ray film