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Feeding of selected dihydroflavonols (that is, dihydroquercetin ( 10 ), dihydrokaempferol ( 17 ) and dihydromyricetin ( 18 )) led to the formation of the corresponding coloured and stable anthocyanidin-3- O -glucosides, namely cyanidin-3- O -glucoside ( 13 ), pelargonidin-3- O -glucoside ( 14 ) and delphinidin-3- O -glucoside ( 15 ), underscoring the arGSTs’ biosynthetic relevance in the formation of additional natural pigments

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Consequently, a “lipid-inflammation” vicious cycle arises in the OA joint microenvironment