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Moreover, the estimated mortality rates of 2.4% and 5.7% for cancers of the lip and oral cavity and the esophagus respectively, and 8.4% along with 11.5% individually for stomach and colorectum cancers, indicated that digestive cancers serve as huge burden for human health ( Precancerous lesions, also known as premalignant lesions, are epithelial aberrant alterations that possess the potential to progress into cancers if left untreated