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Treated mice showed increased proportions of larger, healthier muscle fibers and decreased intramyocellular lipid content, indicating enhanced fat oxidation capacity within muscle tissue
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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, 101 thereby being roughly four times higher than those in normal rats
