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Pretreatment of RAW 264.7 macrophage cells with GHK-Cu has been shown to significantly decrease ROS levels induced by lipopolysaccharide (LPS), increase levels of SOD activities and total GSH, and decrease levels of TNF-α and IL-6 production through the suppression of NF-κB p65 and p38 MAPK signaling [22]

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The study documented that the AEDG peptide increased synthesis of four key neurogenic differentiation markers: Nestin, GAP43, β-Tubulin III, and Doublecortin