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Results demonstrated that elevated plasma concentrations of IL-6 are strongly associated with the need for mechanical ventilation ( p = 1.2 × 10 –5 ) and respiratory failure ( p = 1.7 × 10 –8 )

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Alfenito et al, 1998), and naturally occurring endogenous reactive electrophilic compounds (Marrs, 1996), but may have then been recruited to detoxify anthropogenic exogenous xenobiotics (Kreuz et al, 1996

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