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This multi-route evaluation demonstrated that AOD-9604’s favorable safety profile was not dependent on a specific delivery method, though bioavailability differed between routes

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Specifically, blocking the α1-adrenergic receptors with prazosin or the opioid receptors with nalbuphine interfered with the ability of GLP-1RAs to reduce plasma TNF-α levels, indicating the critical importance of these pathways in the anti-inflammatory effects mediated by GLP-1 activation