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Addiction and Withdrawal Research Animal and limited human pilot studies examined DSIP in withdrawal contexts[12]: Research in opioid withdrawal models suggested DSIP reduced withdrawal symptom severity Pilot studies in alcoholic and opiate-dependent patients reported improvements in withdrawal symptoms Effects on monoamine oxidase A (MAO-A) activity proposed as a contributing mechanism No large-scale or placebo-controlled human trials have been completed in this area [CALLOUT BOX – Highlighted] Critical Research Context: While DSIP has been the subject of controlled human studies – more than many research peptides – the available human data involves very small samples, older methodology, and primarily intravenous administration

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