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FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms
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In a 2024 review of three peptides, the FDA noted side effects like increased heart rate, chest tightening, headache, nausea, diarrhea, and elevated liver enzymes, as well as skin irritation and pain at the injection site
