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Treated animals exhibited reduced interest in their surroundings and repetitive self-injurious behavior 4 weeks after the termination of treatment, possibly due to the downregulation of the OXTR over time [88]

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Recent evidence suggests that some patients with FM have autoantibodies targeting gangliosides, transient receptor potential vanilloid 1 (TRPV1), serotonin 5-HT1A receptors, GABA receptors or fibroblast growth factor 3 [15,16]