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Figure 6 Nuclear GSTP Inhibits HMGB1 Phosphorylation and Increases its DNA-Binding Affinity Classic protein kinase C has been reported to enter the nucleus and act as an upstream kinase of HMGB1 in LPS-stimulated macrophages and promotes HMGB1 to export from the nucleus to cytoplasm (29, 30)

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Perlmutter has been honored with the Linus Pauling Award for his innovative approaches to neurological disorders