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In contrast, M2 macrophages, induced by IL-4, IL-13, IL-10, or glucocorticoids, produce anti-inflammatory cytokines, primarily TGF-β and IL-10 (90)
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EPS of Lactobacillus species engage with TLR2, stimulating the PI3K/Akt/mTOR pathway to enhance IFN-γ production and restore NK cell cytotoxicity suppressed in SLE ( Figure 2 ) (113)