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Some major mechanisms by which bacteria interact with the human host is through fermenting and producing metabolites such as short-chain fatty acids, like acetate, propionate, and butyrate, as well as more complex metabolites such as the hormones serotonin (5-HT) [145,146], cholecystokinin (CCK), gastric inhibitory peptide (GIP) and glucagon-like peptide 1 (GLP-1) [147], and various vitamins [147]