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Common triggers of mast cell activation include: Food allergens (dairy, gluten, alcohol, fermented foods) Environmental toxins (heavy metals, chemicals and VOCs) Stress and trauma Chronic infections (Lyme, Epstein-Barr, Candida, SIBO) Mold and mycotoxin exposure When mast cells are constantly activated, histamine release becomes excessive, leading to chronic inflammation, tissue damage, and widespread symptoms that seem to come from nowhere