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Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has well-established weight-loss benefits. Cagrilintide, a long-acting analogue of the satiety hormone amylin, has shown promise for weight loss in early trials. The potential benefit

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In a phase 3a study of adults with early-stage type 2 diabetes inadequately controlled with diet and exercise, once-weekly cagrilintide–semaglutide reduced HbA1c vs placebo and was associated with body weight reductions over

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Cagrilintide–semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study

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